Publications

Research Publications

  1. Fang, J.S., Hatch, C.J., Andrejecsk, J., van Trigt, W., Juat, D., Chen, Y.-H., Matsumoto, S., Lee, A.P., Hughes, C.C.W. A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions. (preprint). Bioarxiv: doi.org/10.1101/2024.03.11.584490 
  2. Hatch, C.J., Piombo, S., Fang, J.S., Gach, J., Ewald, M., van Trigt, W., Coon, B.G., Tong, J.M., Forthal, D., Hughes, C.C.W. SARS-CoV-2 infection of endothelial cells, dependent on flow-induced ACE2 expression, drives hypercytokinemia in a vascularized microphysiological system. 2024. Front. Cardiovasc. Med. 11:1360364.
  3. Looker, E.K., Aan, F., Hatch, C.J., Hughes, C.C.W., Matter, M., Fang, J.S. Cx40 suppresses sprouting angiogenesis in vitro. 2023. Bioelectricity 5(4): 307-317.
  4. Fang, J.S. and Ek-Vitorin, J. Connexins: A brief overview. 2023. Bioelectricity. 5(3): 153-163. (review)
  5. Fang, J.S. and Ek-Vitorin, J. Connexin Connections: A Special Issue on Gap Junctions. 2023. Bioelectricity. 5(3): 151-152.
  6. Acharya, B.R., Fang, J.S., Jeffry, E.D., Genet, G., Vasavada, H., Chavkin, N.W., Nelson, E.A., Sheynkman, G.M., Hirschi, K.K. Connexin 37 Sequestering of Activated-ERK in the Cytoplasm Promotes p27-mediated Endothelial Cell Cycle Arrest. 2023. Life Sci. Alliances. 6(8): e202201685.
  7. Ruiz, E., Alhassan, S.O., Errami, Y., Abd Elmageed, Z.Y., Fang, J.S., Wang, G., Brooks, M.A., Abi-Rached, J.A., Kandil, E., Zerfaoui, M. A predictive model of adaptive resistance to bRAF/MEK inhibitors in melanoma. 2023. J. Mol. Sci. 24(9): 8407.
  8. Genet, N., Genet, G., Fang, J.S., Chavkin, N.W., Vasavada, H.H., Goldberg, J.S., Acharya, B., Bhatt, N., Baker, K., McDonell, S., Huba, M.R., Ma, G., Eichmann, A., Thomas, J.L., ffrench-Constant, C., Hirschi, K.K. Connexin 43-mediated Neurovascular Interactions Regulate Neurogenesis in the Adult Brain Subventricular Zone. 2023. Cell Reports. 42(4): 112371.
  9. Fang, J.S. and Burt, J.M. Connexin37 Regulates Cell Cycle in the Vasculature. 2022. J. Vasc. Res. (review)
  10. Coon, B.G., Timalsina, S., Astone, M., Zhaung, Z., Fang, J.S., Han, J., Themen, J., Chung, M., Yang, Y., Jain, M., Hirschi, K.K., Yamamoto, A., Trudeau, L.-E., Santoro, M., Schwartz, M.A. A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells. 2022. J. Cell Biol. 221 (7): e202109144
  11. Fang, J.S.*, Hultgren, N.W.*, and Hughes, C.C.W. Regulation of Partial Endothelial-to-Mesenchymal Transition in Angiogenesis. 2021. Front. Cell Dev. Biol. 9:702021. (review)
  12. Hultgren, N.W., Fang, J.S., Ziegler, M.E., Ramirez, R.N., Phan, D.T.T., Hatch, M.M.S., Welch-Reardon, K.M., Paniagua, A.E., Kim, L.S., Shon, N.N., Williams, D.S., Mortazavi, A., Hughes, C.C.W. Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis. 2020. Nat. Commun. 11:5400.
  13. Fang, J.S. and Hirschi, K.K. Molecular Regulation of Arteriovenous Endothelial Cell Specification. 2019. F1000Research. 8:1208. (review)
  14. Fang, J.S., Coon, B.G., Gillis, N., Qiu, J., Chen, Z., Chittenden, T.W., Burt, J.M., Schwartz, M.A., Hirschi, K.K. Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. 2017. Nat. Commun. 8(1): 2149.
  15. Yu, P., Wilhelm, K.*, Dubrac, A.*, Tung, J.S.*, Alves, T.C., Fang, J.S., Xie, Y., Zhu, J., Chen, Z., De Smet, F., Zhang, J., Jin, S.W., Sun, L., Sun, H., Kibbey, R., Hirschi, K.K., Hay, N., Carmeliet, P., Chittenden, T.W., Eichmann, A., Potente, M., Simons, M. FGF-dependent Metabolic Control of Lymphatic Development. 2017. Nature. 545(7653): 224-228.
  16. Wang, Y., Baeyens, N., Corti, F., Coon, B., Fang, J.S., Jin, Y., Zhang, J., Hirschi, K.K., Schwartz, M.A., Simons, M. Syndecan 4 controls lymphatic vasculature remodeling during embryonic development. 2016. Development. 43(23): 4441-4451.
  17. Zou, S., Teixeira, A.M., Kostadima, M., Astle, W.J., Radhakrishnan, A., Simon, L.M., Truman, L., Fang, J.S., Hwa, J., Zhang, P., van der Harst, P. Bray, P.F., Ouwehand, W.H., Frontini, M., Krause, D.S. SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. 2017. PLoS One. 12(5): e0178095.
  18. Ola, R., Dubrac, A., Han, J., Fang, J.S., Zheng, F., Larrivee, B., Lee, M., Urarte, A.A., Genet, G., Hirschi, K.K., Sessa, W.C., Canals, F.V., Graupera, M., Young, L.H., Oh, S.O., Eichmann, A. PI3 Kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. 2016. Nat. Commun. 7:13650.
  19. Fang, J.S.*, Gritz, E.C.*, Marcelo, K.L., Hirschi, K.K. Isolation of Murine Embryonic Hemogenic Endothelial Cells. 2016. J. Vis. Exp. 112.
  20. Coon, B.G., Baeyens, N., Han, J., Budatha, M., Ross, T.D., Fang, S., Yun, S., Eichmann, A, Schwartz, M.A. Intra-membrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex. 2015. J. Cell Biol. 208 (7): 975-86.
  21. Fang, J.S.*, Dai, C.*, Kurjiaka, D.T., Burt, J.M., Hirschi, K.K. Connexin45 expression in mesenchymal cells supports endothelial-induced mural cell differentiation. 2013. Thromb. Vasc. Biol. 33(2): 352-8.
  22. Fang, J.S., Angelov, S.N., Simon, A.M., Burt, J.M. Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40-/-mice. 2013. Am. J. Physiol. Heart Circ. Physiol. 304(6): H816-27.
  23. Fang, J.S., Angelov, S.N., Simon, A.M., Burt, J.M. Cx40 is required for, and Cx37 limits, post-ischemic hindlimb reperfusion, survival and recovery. 2012. J. Vasc. Res. 49(1): 2-12.
  24. Fang, J.S., Angelov, S.N., Simon, A.M., Burt, J.M. Cx37 deletion enhances vascular growth and facilitates ischemic limb recovery. 2011. Am. J. Physiol. Heart Circ. Physiol. 301(5): H1872-81.
  25. Migliati, E., Meurice, N., DuBois P., Fang, J.S., Somasekharam, S., Beckett, E., Flynn, G., Yool, A.J. Inhibition of Aquaporin-1 and Aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding site. 2009. J. Pharm. 76(1): 105-112.
  26. Burt, J.M., Nelson, T.K., Simon, A.M., Fang, J.S. Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells. 2008. Am. J. Physiol. Cell Physiol. 295: C1103-C1112
  27. Fang, J.S., Gillies, R.D., Gatenby, R.A. Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. 2008. Semin. Cancer Biol. 18(5): 330-337. (review)
  28. Danforth, B.N., Sipes, S., Fang, J., Brady, S. The history of early bee diversification based on five genes plus morphology. 2006. Proc. Natl. Acad. Sci. 103(41): 15118-15123.
  29. Danforth, B.N., Fang, J., Sipes, S. Analysis of family-level relationships in bees (Hymenoptera: Apiformes) using 28S and two previously unexplored nuclear genes: CAD and RNA polymerase II. 2006. J. Phylo. Evol. 39: 358-372.
  30. Danforth, B.N., Lin, C.P., Fang, J. How do insect nuclear ribosomal genes compare to protein-coding genes in phylogenetic utility and nucleotide substitution patterns? 2005. Sys. Ent. 30: 549-562.